Does Tramadol Cause Serotonin Syndrome?

Tramadol and Serotonin SyndromeTramadol is the generic name of commercially popular drug known as Conzip or Ultram used as an analgesic or pain relieving agent. Tramadol is categorized under narcotic pain meds which means that the drug is placed under the category Rx meaning it is available only on the prescription of a certified Doctor. Now, serotonin syndrome is an umbrella term for a group of syndromes associated with central nerves system caused by a drug interaction which results in overdose, misuse or as a side effect. The effects may be life threatening inducing effects in a cognitive, autonomic and somatic behavior of the brain. There is a lot of drugs with similar effects among one those is Tramadol, apart from whose analgesic property they can also cause serotonin syndrome. It is more like a group of symptoms that are exhibited when a drug user goes wrong, so terms like serotonin toxicity or poisoning it the suitable term.
According to a case study published in an online journal, reported a case of serotonin toxicity laid the foundation for extending study regarding the tramadol and serotonin syndrome. According to the case, a lady who was under treatment for an occasional migraine was admitted to a hospital in the year 2006 due to a drug overdose. She was originally prescribed with alprazolam popularly known as Xanax for her condition but due to the poor response, she ingested tramadol in combination with acetaminophen tablet which led to a condition of hallucination, narcotic instability, seizure etc. Upon a thorough study, Doctors ruled out the overdose of tramadol created a hike in serotonin production that led to an altered brain activity.

What are the signs and symptoms of serotonin syndrome?

Symptoms might look similar to that of normal side effect of the drug in the initial stage, but later on, the symptoms go worse causing severe muscle twitching and hallucination accompanied by other problems.

The initial symptoms include:

  • Elevated heart rate
  • Excessive sweating
  • Moderate and random muscle twitching
  • Difficulty in breathing
  • Hyper reflex.

The overall signs and symptoms may be classified into three categories, cognitive or related to mind, autonomic that is related with involuntary & internal organs and somatic effects related to voluntary nerves system

Cognitive effects

  • Hallucination
  • Disorientation
  • Hypertension
  • Confusion

Autonomic effects

  • Sweating
  • Shivering
  • Feeling tremors
  • Nausea
  • Xerostomia

Somatic Effects

  • Hyper-reflex
  • Muscle twitching or myoclonus

How to avoid serotonin syndrome during tramadol medication?

In order to avoid serotonin poisoning during tramadol medication simply follow your Doctor word by word. Tramadol is an analgesic at the same time, it possesses other narcotic activities too, which depends on the concentration being prescribed. So make sure that you don’t self-medicate or abuse the tramadol drug. Always take the supervision of a trained medical practitioner before taking tramadol for arthritis pain.

If you suspect any of the above symptoms seek medical attention at the earliest, some other complication other than serotonin syndrome is tramadol tolerance and addiction.The best way to avoid this is to get the prescription for tramadol from a Doctor and proceed with the medication under the medical supervision. If you plan to purchase Tramadol then try tramadol online pharmacy in order to save a decent amount of money after shopping!