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What is Tramadol?

What is TramadolTramadol is a prescription medication which is prescribed for treating pain in the body irrespective of the pain ranging from moderate to severe. Tramadol is the generic formulation of its brand counterpart Ultram. The drug is sold as Ultram in the US, as Ralivia and Dromodol along with other names elsewhere in the world. This drug is known to work by changing the way the central nervous system responds to pain. It is also known as a narcotic-like a pain killer. The medicine is also available in an extended release form for healing round the clock treatment of pain. However, the extended release Tramadol is not advised on an as and when needed basis for treating pain.

Tramadol appearance and physical properties

tramadol appearanceTramadol appears to be as white to off-white powder that is crystalline and is also odorless. It has a melting point of about 180 to 184 degree Celsius. The drug is a synthetic chemical compound that is used in the treatment of pain and discomfort. It is available in the form of an injected med and works centrally rather than working locally. Due to the wide range of pain thresholds that Tramadol can handle, it is prescribed for treating quite a long list of uncomfortable conditions like motor neuron disease, restless leg syndrome, fibromyalgia, rheumatoid arthritis and other such conditions.

Tramadol structure

Tramadol StructureTramadol is a relatively weak receptor agonist of M-opioid receptor. But, the body metabolizes Tramadol to O-desmethyltramadol which is a further more powerful receptor of M-opioid. Structure-wise, Tramadol appears to be similar to that of codeine but has a stripped down variant. Codeine and Tramadol have a shared 3-methyl ether structure and both of these compounds are metabolized in the liver in the same pathway. The final metabolized form of Tramadol is o-desmethyltramadol. This pain relieving medicine is available in generic forms under various brand names. There are many manufacturers that prepare Tramadol under their brand names. Tramadol can be availed in the form of injections, intramuscular or even as intravenous form. One can also avail the drug as effervescent tablets, suppository, phial, and also in powdered forms.

Tramadol benefits

Tramadol BenefitsUsage of Tramadol as a serotonin and norepinephrine reuptake inhibitor should be done only under strict supervision of qualified health expert or a psychiatrist. Tramadol is effective in two ways. One is that about 20% of its painkilling effects are due to the opioids and the 80% are the ingredients that impede the reuptake of serotonin and norepinephrine which are two chemicals that are associated with the mood and are responsive to pain. Since Tramadol comprises of fewer opioid properties than the other painkillers that are addictive like oxycodone, hydrocodone, and morphine, many physicians consider this to be safe.